Summary of
Modern Studies on Huanglian Qingwei (Sweet
Breath & Healthy Gum™)Capsule
Chinese Use: Gingivitis, paradentitis, parulis, stomatitis, glossitis, fever in children, acne, cholecystitis, bacillary dysentery.
Modern studies on
pharmacodynamical reveal that
this product yields actions of bacteriostasis, anti-inflammation, Sedation,
analgesia, hemostasis and improving phagocytosis of macrophage.
1. Bacteriostasis: The Decoction of this product yields
action on inhibiting staphylococcus aureus, pseudomonas aeruginosa, but the
action is not so strong.
2. Improving the phagocytosis of macrophage: 5% solution
of this product is administered to mice through gastric perfusion 0.5ml/mouse,
once daily foe 3 successive days. The phagocytosis of abdominal macrophage is
markedly strengthened, with marked increase of phagocytic percentage and index,
demonstrating that the therapeutic action of this product may not be its direct
action, rather, it may be attributed to the effect of strengthening the organic
specific immunity.
3. Anti-inflammation: (1)Inhibition of tissue
inflammation and granulation: By injecting 5% solution of this product 10ml/kg
into the abdomen b.i.d. for 3 consecutive days, marked inhibition on claw
inflammation induced by albumen in rat. Granulation induced by paper-piece
method, q.d. administered by abdominal injection of 5% of solution of this
product 10ml/kg q.d. in rat for 7 successive days, the formation of granulation
is markedly inhibited. (2)Radix Angelica Sinensis and Cortex Moutau radicis all
yield anti-inflammatory action when used individually.
4. Sedation, analgesia: Radix Angelica senensis and
Rhizoma Cimicifugae all yield sedative and analgesic effect when applied individually.
5. Hemostasis: Radix Rehmanniae improves blood
congulation, Rhizoma Cimicifugae markedly shortens the coagulation time.
Toxicological studies: 10
mice weighing 18~20g are perfused gastrically with 100%. Decoction of this
product 0.4ml/mouse. Observations is made for 3 days, with no fatal mouse
found. The quantity given is 150 times that of each kg of body weight in normal
adult.
Clinically, this product was used in gingivitis, periodontitis,
gingival abscess, stomatitis, glossitis, infantile fever, swelling of lips in
infant, acne, cholecystitis, bacillary dysentery.
1.
Diseases of the mouth
and teeth: (1) Acute gingivitis, periodontitis: 103 cases of acute gingivitis
were treated with this product plus Yunu Decoction; 94 cases were cured; 9
cases were markedly effective. 56 cases of acute periodontitis with this
product, the total effective rate being 98.2%. (2) Stubborn stomatitis: 75
cases were treated with this product with additives. All cases were cured. With
3~9 doses, generally 6 doses; 86 cases were treated with this product with
additive, with 6 days constituting a therapeutic course. Generally 1~2 courses
were administered, during which all other medication are interrupted. 73 cases
were cured, 12 markedly effective, 1 case ineffective, the total effective rate
being 98.8%. (3) Recurrent aphthae stomatitis: 56 cases were treated with this
product plus additives. 31 cases were markedly effective; 18 cases effective;
the total effective rate being 87.5%. (4) Gingivitis and mucous membrane inflammation:
21 cases of periapical inflammation were treated with this product plus Flos
Lonicerae, Herba Taraxaci. 17 cases were cured; 4 cases, markedly effective.
For serous type, the disorder can be readily cured, while for pyogenic type, it
also healed without pyogenation. 40 cases of acute periodontits were treated
with this product with additives, 27 cases were cured; 12 cases, effective; 1
case, ineffective. (5)Herpetic Pharyngitis: 192 cases were treated with this
product with additives. All cases were cured.
2.
Infantile fever and
swelling of the lips: 60 cases were treated with this product, with analgin and
injection of Radix Bupleuri as control. Result showed that 60 cases in the
treatment group, 37 cases were cured; 20, ameliorated; 16, ineffective. The
effective rate being 68%.
3.
Acne: 50 cases of acne
vulgaris were treated with this product with additives, 39 cases were cured; 8,
markedly effective; 2, effective; 1 , ineffective. Generally, effects were
revealed 3~9 days after medication.
Most cases were markedly effective or cured after one course of treatment.
Excerpt from A Guide to TCM Products, China Academy
of Traditional Chinese Medicine, 2003
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.