PlasminPlus

is a dietary supplement for those who have the need to improve their blood circulation, especially those who suffer from ischemic cerebral cardiovascular difficulties, both acute and chronic, such as Cerebral thrombus - Cerebral embolism - Pulmonary embolism - Angitis - Myocardial infarction - Hyperplasminemia - Platelet Hypercoagulability - Deep Vein Thrombosis - Traveler's Thrombosis - Blood Clots - Tendency to develop thrombus.

A Brief Summary of PlasminPlus's History

· In 1970 Professor Shan Hongren discovered enzymatic functions of extract from earthworms.

· PlasminPlus was approved by the Chinese government as a new medicine in 1997.

· PlasminPlus was endorsed by the China Gerontology Foundation in 1997.

· PlasminPlus was endorsed by the China Gerontology Association Rehabilitation Committee in 1998.

· PlasminPlus was listed as a key product for promotion by China Medical Society in 1999.

· PlasminPlus was Listed by the China National Supervisory and administrative Commission as a "Class 2" nationally protected TCM formula in 1999.

PlasminPlus was included in the National Catalogue of Basic Medicine in 2000.

PlasminPlus is used extensively and with great success in China. In China it is used for stroke victims that have suffered paralysis or brain damage, blood clots in the legs and brain, poor circulation, clogged arteries, and to prevent thrombosis associated with airline travel. It is also used for those with diabetic complications such as nervous pathological changes, and micro-circulation disturbances. According to Chinese research, it is the only natural product known to exist that can break-down and dissolve blood clots with no side-effects.

This Is The Finest Herbal Thrombosis Product available.

Comments by China’s Doctors and Research Scientists

Dong Ziqiang, Associate Professor and Doctor of the Chinese Medicine Hospital of Pingdingshan City, Henan Province:
As a breakthrough in the medicine category, the Thrombo-Dissoving Capsule, PlasminPlus is very effective and unique in treating cerebral infarction, especially for the sequlae of the cerebral infarction, having important signification for improving the life-quality of the patients and reducing the burdens of the families and the society.

PlasminPlus is obviously effective for treating the temporal cerebral ischemia and effective to prevent the cerebral infarction; in addition, the Capsule is well accepted by the patients and convenient for administration and without toxical side effects. PlasminPlus is truly an ideal medicine for preventing and treating the cerebral infarction and for promoting the rehabilitation of such patients.

Sun Hongli, The Chief Doctor of the Chinese Medicine Hospital of Pingdingshan City, Henan Province.
The Thrombo-Dissolving Capsule, PlasminPlus is very effective in treating Cardiovascular Disease. The fibrinolysin, fibrinolysogen activator and collagenase contained in the product have the ability to rapidly and completely dissolve the newly formed or remote thrombi. Therefore, the Capsule has obvious effects for treating chest pain, chest boredness and palpitation, especially effective for the prevention and treatment of coronary diseases and the myocardial infarction.

Wu Shijiu, Professor of the Diabetes Division of the South Hospital; attached to the First Military Medical University of Guangshou City:
The Thrombo-dissolving capsule, PlasminPlus, not only has the effect to reduce the high sugar and fat levels of diabetes, but also the ability to treat the complications such as peripheral neuron-pathological changes, limb numbness and limb pain. PlasminPlus opens a new page for the treatment of diabetes and its complications and is worthy to be more widely used.

He Guofen, Head Professor of the Endocrine Disease Division of the First Clinical Hospital attached to the Shanxi Medical University:
The Thrombo-Dissoving capsule, PlasminPlus has the ability to impede the thrombi, reduce the blood viscosity, dissolve the fibrinogen, reduce the cholesterol, and improve the microcirculation. PlasminPlus is convenient for administration and without side effects. It is suitable for treating the chronic complications of diabetes, especially for treating the cerebral infarction successfully.

Wei Lihua, Professor and Head of the Neuron-Internal Division of the First Clinical Hospital attached to the Shanxi Medical University.
The Thrombo-dissolving capsule, PlasminPlus is a new medicine with definitive curative effects, without toxical and obvious side-effects. PlasminPlus should be more widely used in order to provide the patients with a convenient medicine with short treatment periods and good curative effects.

Xu Kaijian, Wu Guoting, Yang Youshan, Specialists of the Clinical Pharmacological Base of the Harbin Medical University under the Ministry of Public Health:
PlasminPlus is truly a new and convenient medicine with a short treatment period and good curative effects. The capsule is a safe and reliable medicine for treating the cerebral infarction and is worthy to be more widely used clinically.

Deng Xuewen, Specialist Doctor of the Neurons Disease Division of the Yantai Medical College in Yantai City:
PlasminPlus is truly an ideal medicine for treating the thrombotic dieseases; having very strong ability to reduce blood viscosity and cholesterol as well as the advantages of no toxical side effects.

Li Bilin, Specialist Doctor of the Internal Disease Division of Hospital 264 of the PLA:
PlasminPlus can reduce the aggregation of the blood platelets, reduce the blood sugar, dissove the thrombi and improve the blood supply of the heart and the brain. The curative effects for treating the cerebral infarction are confirmed. In addition, PlasminPlus has preventive effects to the deseases, having the ability to reduce the blood sugar and no toxical side effects.

This Is The Finest Herbal Thrombosis Product availble.

How and Why plasminPlus Works?

Hemostasis is one of the many defensive mechanisms that protect our body from damages. When a blood vessel is cut, a repair mechanism is activated that eventually seals the cut and prevents further blood loss. This lifesaving process becomes life threatening when clots (thrombi) form within functional blood vessels (thrombosis) Thrombosis tends to occur in blood vessels damaged by arterosclerosis or in vessels with a sluggish blood flow. In veins, portions of the thrombi (emboli) may break off and pass along the bloodstream to become lodged in the arteries of the heart, the lung, the kidney or capillaries to the brain. Three weeks after formation a thrombus is closed up with a collagen shell. This is the most difficult thing to remove. Attempts were made and numerous drugs developed but the result was disappointing at best. It was obvious that collagen can only be dissolved by a specific collagenase, but this specific collagenase can not be synthesized in the human body. So it was predicted that whoever finds the right collagenase will have the key to curing thrombus.

We found the right collagenase! And it comes from the enzymes of a special kind of earthworm.

Chinese have used earthworm for thousands of years. The famous Compendium Materia Medica describes it as salty in taste, cold in property, and efficacious in clearing heat, invigorating blood circulation, dissolving stasis, opening up channels, curing stroke, hemiplegia and infantile convulsion,?and pointed out that earthworm has self- dissolving ingredient.

Modern scientific research verified the Chinese use of earthworm and identified three thrombolytic enzymes: fibrinolysin (plasmin), profibrinolysin activator and collagenase.

Plasmin is an enteric capsule made of special species of earthworm with state of the art biological engineering technology.

How it works: The PlasminPlus capsule carries plasmin into intestines and opens up and plasmin is absorbed into blood circulation system. As plasmin has a strong affinity to thrombus it attaches to it. The specific collagenase discomposes the collagen shell and fibrinnolysin enters the thrombus with profibrinolysin activator which activates more fibrinolysin. Fibrinolysin dissolves the fibrin inside the thrombus. As thrombus disappears the blood vessel is opened and normal blood circulation restored.

PlasminPlus is nontoxic and good for long term use without any side effect. It helps maintain a healthy balance between hemolysis and hemostasis, improves micro circulation, repairs damaged nerve cells and reduce blood sugar. It provides many trace elements and vitamins needed by the human body.

PlasminPlus is used extensively and with great success in China. In China it is used for stroke victims that have suffered paralysis or brain damage, blood clots in the legs and brain, poor circulation, clogged arteries, and to prevent thrombosis associated with airline travel.

It is also used for those with diabetic complications such as nervous pathological changes, and micro-circulation disturbances According to Chinese research, it is the only product known to exist that can break-down and dissolve blood clots with no side-effects.

There have been numerous clinical trials of PlasminPlus in China. The following summary is consistent with all of the clinical trials to date.

Observations of 30 cases of Cerebral Infarct Treatment by Thrombus Dissolver Capsule (PlasminPlus)

Yunnan Provincial Communication Central Hospital Cerebrovascular Disease Department ?Wang Zhipu

As a frequent cerebrovascular disease, cerebral infarction makes 50%-60% of acute cerebrocascular disease (1). The death rate due to the cerebrovascular diseases has become the first of 3 main death causes of middle-age and elderly persons (2). In accordance with the epidemiological investigation in recent years in China, there are 1.05 million new cerebrovascular patients annually and 1 million deaths, two-thirds of the first onsets are patients over 60 years of age.

According to the general opinion now, the occurrence frequency of the cerebral infarction is increased with age, higher in males than in females (3). Therefore, prevention and treatment has been becoming an urgent task. At present, the thrombo-dissolving treatment has got successful progress in the country and abroad; but the time-window of successful treatments is very narrow, the measurement and examination must be done accurately, threatened by the danger of cerebro-bleeding. An oral, effective and safe medicine for thrombo-dissolving is needed to overcome the above-said disadvantages.

From November 1998 to January 1999, we have used the Thrombo-Dissolving Capsule (PlasminPlus) to treat 30 cases of cerebral infarction and good curative effects were attained. Not only the clinical symptoms, but the physical signs are obviously improved, the hemorheology and the nail-fold microcirculation are also obviously improved.

Objectives and Methods:
1. Case Selection: All the cases are conformed to diagnostic standards formulated by the second national cerebrovascular disease congress and examined with the CT or MRI to be cerebral infarction (4). Total: 30 cases, 17 cases male, 13 cases female; average age 67.2 years. In the 30 cases, 16 cases were of acute period (less than 1 month since the onset), 14 cases of restore period (1-2 years since the onsets).

2. Methods of administration: The Capsule (PlasminPlus) was orally administered, 3 capsules each, t.i.d., a half hour before meals; 15 days as a treatment period. During the treatment, no anti-coagulation medicines or blood-promoting medicines were taken. Before and after the administration of the medicine, the liver and kidney functions, the blood sugar, the blood fat, the D-dipolymer, hemorheology and the nail-fold microcirculation were examined.

3. Evaluation of the efficiency: In accordance with the standard of the Edinburgh research group revised by the cerebrovascular, rehabilitation society of Yunnan Province, the efficiency was evaluated with ponts before and after the administration. Not serious = 0-15 points; Middle = 16-30 points; serious = 31-45 points.

The efficiency evaluation: 1 basically cured, 2 obviously improved; the neuro-functional damages are 80% eliminated, the patients can be partly self-cared, 3 improved: the neuron-functional damages are 50% eliminated, 4 No changes: the accumulated points of improvement are less than 5 points, 5 worsened: the accumulated points of worsening are more than 5 points, and 6 death.

Results: After the treatment of 15 days (one treatment period) of the 30 cases, 8 cases basically cured (26.67%). 1 case obviously improved (3.33%), 19 cases improved (63.33%), 2 cases no changes (6.67%), with a total efficiency rate of 93.33%. Of the 12 cases of lacune type infarction, 8 cases basically cured, 1 case obviously improved, 3 cases improved, with a total efficiency rate of 100%. Of the 19 cases improved, 12 cases of basal joint infarction, 4 cases blood cerebral infarction, 3 cases lobar infarction. The 2 cases of no changes are restore-period patients with areal cerebral infarction.

The D-dipolymer was measured with emulsion qualitical agent semi-quantitically positive: >200 ng/L. Of the 30 cases, 6 cases are positive (20%, 341-624 ng/L) before the treatment; 22 cases are positive (73.33%, 526-814 ng/L) after the treatment (P<0.01). The measurement of FDP in the blood (Positive: >5? g/mL): no positive cases before the treatment; 16 cases are positive (53%, 6.47-12.2? g/mL) after the treatment. The comparative examinations of liver and kidney functions before and after the treatment give similar results. No toxical side effects were found during the treatments.

Disscussions:
The Thrombo-Dissolving Capsule (PlasminPlus) is a protein hydrolase extracted from the special earthworm containing the fibrinolysokinase, its activator and collagenase, and having the obvious effects to remove fibrin, reduce coagulation and dissolve the thrombi, in particular, to dissolve the old thrombi.

The 30 cases of the treatment group were treated with the Capsule for a treatment-period, with the results that the fibrin in blood is reduced; the D-dipolymer and FDP are increased. The treatment efficiency is obvious, proving the strong thrombo-dissolving ability of the Capsule (5). The nail-fold microcirculation and hemorheology of the patients are obviously improved; the damages of neurons systems of them are thus eliminated, resulting in the total efficiency rate of 93.33%. Based on the anti-coagulating ability of the Capsule, the blood-deficient cerebral infarctions can be prevented with the medicine.

The main advantages of the Capsule are the convenient administration and no toxical side effects; the Capsule is also effective for the patients of cerebral infarction in the acute period, the restore period or the sequelae period. It is not necessary to do complicated and time-consuming examinations and the patients are not needed to stay in the hospital. The examination data and the clinical curative effects of the 30 cases before and after the treatment are similar, because the treat-period is relatively short. If the patient could take the Capsule long-term, the treatment effects would be surely better.

In 1997, our division has accepted 2 cases of areal cerebral infarction due to the left-brain artery thrombi; after a thrombo-dissolving treatment and a systematic rehabilitation, the patients can leave the hospital on foot with the help of one other person, but having remaining symptoms such as drool, anandia, no muscular force of right upper-limb.

After 3-5 treatment periods with oral administration of PlasminPlus, the language functions are basically restored, the patients can stably go without the support of another person, the muscular force of the right upper-limb is restored, the patients can be self-cared. This shows that the Capsule can be taken long-term and has curative effects for patients of sequela-periods.

Reference Literatures:
1. Dai Ziying: Practical Internal Medicine, 8th edition, People Health Publishing House, Beijing, 1986, P. 2026. 2. Wang Dexin: Senile Neurology, 1st edition, People Health Publishing House, Beijing, 1090, P. 110. 3. Wang Zhipu: Danger analysis of 811 cases of cerebral infarction. Jiaotong Medicine? 1996: 10(3), P.22. 4. Wang Dexin: Key points of cerebrovascular disease diagnosis formulated by the second national congress on cerebrovascular diseases in 1986, Journal of Chinese Neurology? 1988, 21(1), P.60. 5. Wang Zhipu: The diagnostical signification of the D-dipolymer on the cerebrovascular diseases, Jiaotong Medicine 1997: 11(2), P. 154.