Summary of modern studies on Qilong Yufeng(Cerebral-Cardiovascular Cleanser™) Capsule

Chinese Use: Cerebrovascular, cardiovascular and neurovascular diseases.

Modern studies on pharmacodynamics reveal that this product yields actions of anti-thrombosis, thrombolysis, dilatation of brain vessels and increasing of its blood flow, improvement of hematology, prevention of acute brain injury, restoration of injured nerve, inhibition of platelet aggregation, cardio tonic, inhibition of plaque formation in atherosclerosis, lowering blood lipid, increasing the tolerance to anoxia and anti-fatigue.

1. Anti-thrombosis and thrombolysis: Buyang Huanwu decoction 2g/kg administration by stomach perfusion can markedly inhibit the thrombosis formation in rat. Infusion of the solution of Buyang Huanwu decoction into human umbilical vein revealed that the activities of thrombin and fibrinogen are inhibited. To rabbit, Buyang Huanwu decoction 2g/kg is perfused with a result that the thrombolytic action in experimental thrombus in small arteries of rabbit model is strengthened.

2. Dilatation of brain vessels and increasing of its blood flow: By using rheoencephalograph and resistance graph of the fore limbs of rabbit as index, noradrenalin is injected into rabbit vein in a dose of 0.25-05g/kg, when the graphic amplitude reaches its lowest point, Buyang Huanwu decoction 1.5ml/kg i.v. was given for 5-10 minutes, the amplitude is obviously increased, and the blood flow in the brain is also increased persistently for as long as over one hour. The resistance in brain vessel is decreased.

3. Improvement of hematology: Rabbit model of cerebral infarction is prepared by compound method. Buyang Huanwu decoction is perfused 7.5g/rabbit/day for 20 consecutive days, the high viscosity of the whole blood and plasma viscosity ratio decreased. The serum cholesterol content also decreased.

4. Prevention of acute brain injury: Both carotid arteries of rat are fastened to form an acute brain ischemic model. The content of water and Na+ in the brain are used as index. 5 minutes before the re-infusion acute brain ischemia, Buyang Huanwu decoction 14g/kg is injected intraperitoneally, the content of water and Na+ in the brain are greatly decreased, demonstrating that this product can prevent the brain injury caused by re-perfusion in brain ischemia.

5. Restoration of nerve injury: Guinea pig is injured in its spinal cord to cause hind limbs paralysis, the Buyang Huanwu decoction 4.5g/kg is perfused to the stomach 2 times daily for 7 consecutive days. The injured part received histopathologic exam. The injured neuron of control group is 44.1%, while that of experiment group is 26.4%, demonstrating remarkable restoring action. It is also good for recovery of peripheral nerve injury, with great recovery of nerve conduct speed.

6. Cardio tonic: Cat’s papillary muscle is used for in vitro experiment. The actual drug concentration is 0.3-0.5g/ml. After medication, the contraction amplitude is increased with a quantity-effect relation, demonstrating a positive action of muscle muscular strengthening. To anesthetized rabbit with open chest, i.v., of Buyang Huanwu decoction 0.5, 1.0, 2.0g/kg is given. It reveals marked and persistent action of increasing the contraction amplitude of myocardium.

7. Increasing nutrient blood flow in myocardium: Buyang Huanwu decoction is used for gastric perfusion in 4, 8, 16g/kg, the nutrient blood flow increases 1.8%, 132.7%, 192.7% respectively. The last two groups have remarkable increase.

8. Lowering blood lipid and preventing plaque formation in atherosclerosis: Hyperlipidemia and atherosclerotic models are prepared by feeding high fat diet to rabbit. Buyang Huanwu decoction is given for 30 days by gastric perfusion. The serum cholesterol is much lower than the control group with marked vanishing of plaque. The rapid heart beating during the making of the model is decreased. At the same time, increasing of body weight is also inhibited.

9. Increasing the tolerance to anoxia and anti-fatigue: Mice are perfused with Buyang Huanwu decoction 2g/kg once daily for 10 days, The time of tolerance to anoxia and swimming time are greatly prolonged.

10. Anti-inflammation and improvement of immunity: Buyang Huanwu decoction is perfused 10, 20g/kg daily for 10 days. It markedly inhibits the swelling of auricle and inhibits the increased permeability of capillaries induced by di-methyl benzene, increases the weight of immune organs thymus and spleen, increases the specific hemolysin antibody contents and increases phagocytosis of macrophage.

Toxicological studies: Medication for 7 days, the LD₅₀ and 95% average confidence limit is 150.12±6.969/kg. Intravenous injection of this product to mice shows a LD₅₀ and 95% average confidence-limit rate is 149±13g/kg, LD₀ /EDT is 15.7(EDT id the effective trial dose).

Clinically, this product was applied in cerebral vascular and cardio-vascular diseases and nervous vascular disease.

1. Cerebral vascular disease: (1) Acute obliterated ischemic cerebral vascular disease: 50 cases cerebral infarction due to arteriosclerosis were treated. 31 cases were cured, 9 cases markedly effective, 5 cases ameliorated, 5 ineffective. As compared with the control group treated with western drugs, this product is significantly superior in cured and effective rates. (2)Treatment of sequelae of brain injury: 41 cases were treated, 18 cases were cured, 20 ameliorated, 3 ineffective, the total effective rate being 92.7%. (3). Cerebral thrombosis: 60 cases were treated, 24 basically cured, 24 markedly effective, 3 ameliorated, 9 ineffective, the total effective rate being 85%. .

2. Obliterated arteriosclerosis: 49 cases in early stage were treated with this product with additives. The total effective rate is 87%, markedly effective rate 67.3%, improved rate, 20.4%

3. Cardio-vascular diseases: (1) coronary diseases: 103 cases were treated with this product plus iontophoresis, the effective rate was 68%; markedly effective, 17.5%; improved, 50.5%. In the persantine group, the effective rate was 45.2%, markedly effective, 6.5%, improved, 38.7%. (2) Angina pectoris: 52 cases were treated, the total effective rate was 92.3%; markedly effective, 51.9%; effective, 40.4%,;non-effective, 7.7%.

Excerpt from A Guide to TCM Products, China Academy of Traditional Chinese Medicine, 2003

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.