Summary of
modern studies on Gegen Pingya (Blood Pressure Balance™) Capsule
Chinese Use: Hypertension.
Modern studies on pharmacodynamics reveal that Radix Puerariae in this product
yield effects of blood pressure lowering, increasing of blood flow in the brain
and coronary arteries, dilatation of peripheral vessels, antipyretic action,
anti-tumor, inhibition of platelet aggregation and lowering blood sugar.
1.
Lowering blood pressure:
After vein injection of 5-30mg/kg puerarial flavones into anesthetized dog, its
blood pressure lowered. The degree of lowering is proportional to its dosage,
lasting for 5-20 minutes, To high blood pressure dog without anesthetized,
total puerarial flavones is fed for 12 consecutive days, it lowers the
hypertensive action of nor-adrenalin.
2.
Increasing brain blood
flow: Total puerarial flavones 1mg/kg is injected into the carotid arteries of
5 anesthetized dog, the blood flow increases rapidly, especially in the first
1-2 minutes. The average increases reaches 21± 3.5% in 3 minutes. The vessel
resistance lowers 14±2.5%, and is markedly lowers when the dosage increases to
30mg/kg. Brain blood flow also markedly increases.
3.
Dilatation of
peripheral vessel, increasing blood flow: After injection of total puerarial
flavones of 10, 20, 40mg/kg into femoral arteries of anesthetized dog, its
femoral arteries blood flow increases to 22±6.2%, 26±6.9%, 54±15.7% averagely
and respectively after 3 minutes. The vessel resistance lowered to 15±4.6%,
14±6.6 and 27±7.0% respectively, demonstrating that it dilates the peripheral
vessels.
4.
Action on the heart:
(1) Increasing coronary blood flow: 20mg/kg of total puerarial flavones is
injected into 6 dogs’ veins, the coronary blood flow increase from 138±31
before injection to 203±61mmHg/ml/100%, while blood vessel resistance decrease
from 1.15±0.22mmHg/ml/100% before injection to 0.89±0.24mmHg/ml/100% min. This
marked increase in blood flow and decrease of vessel resistance demonstrate
that puerarial flavones possesses rather strong action of dilating coronary
vessel. (2) Improvement of metabolism of cardiac muscle: 30mg/kg of total
puerarial flavones was injected into 9 dogs’ vein. After 3 minutes, the oxygen
pressure in venous blood charged from 7.2±0.4% before injection to 10.6±0.9%,
the oxygen consumption of heart muscle lowers from 11.3±20mg/100g min. before
injection to 8.8±2.9mg/100g min.; venous lactic acid increases from 15.2±2.6%
before injection to 19.0±2, the utilized rate of lactic acid by myocardium
lowers from 41±5% before injection to 23±5%. There is also a marked increase of
pyruvic acid with lowered consumption of pyruvic acid in myocardium. (3)
Anti-acute cardiac ischemia: When 0.6g/kg total flavones is injected into rat’s
vein, an action of anti-acute cardiac ischemia induced by pituitrin can be
observed, thus obviously decreases the ischemia reaction of the heart vessel.
(4). Anti-arrhythmia: Injection or infusion of puerarine can markedly resist
the arrhythmia in rat induced by aconitine and barium chloride. Infusion of
alcohol extract of Radix Puerariae also
resist the arrhythmia, and prevents the ventricular fibrillation in mice
induced by chloroform and barium chloride. There is no obvious difference in anti-arrhythmia
action between puerarine and inderal.
Modern studies on pharmacodynamics on liensinine extracted from Plumula Nelumbinis yields short-term pressure-lowering effect. After it trandforms to quaternary ammonium, the pressure-lowering action is markedly increased and last longer. Methyl liensinine can yield dosage-dependent and rapid depressor action in anesthetized rat, renal rat, DOCA hypertensive rat, anesthetized cat and normal rat and rabbit. Injection of liensisine to vertebral artery and intracrainial injection in the dose of 0.6mg/kg markedly lowers blood pressure, demonstrating that methyl liensinine is an active depressor, yielding direct dilating action on smoothing muscle of vessel. It is also effective in spontaneous hypertension in rat. Depressor action by ig administration of this product can last for 3 hours.
Toxicological studies: Oral
administration of dry powder of alcohol extract of puerarea 10g/kg and 20g/kg
for 3 days yield no toxic reaction, the LD50 of intravenous injection
being 12g/kg. Oral administration of alcohol extract in mice 2g/kg for 2 months
reveals no pathological injury in organs. For hypertension dogs, oral intake of
alcohol extract in dose of 3g/kg for 14 successive days reveals no toxic
reaction.
Clinically, this product is applied in hypertension, coronary disease, angina
pectoris, sudden deafness and nervous headache.
1.
Hypertension: 71 cases
were treated, the effect for headache is 82.9%, the total effective rate is
51.8%; for vertigo, 72%, markedly effective rate 33.4%; for neck pain, 84.7%,
markedly effective rate 50%
2.
Coronary disease,
angina pectoris: 120 cases were treated with a total effective rate of 91%,
markedly effective rate 68.6% and improvement of EKG 51.2%
3.
Sudden deafness: 176
cases were treated, with a total effective rate of 79.5%, markedly effective
rate 23.3%.
4.
Nervous headache: 42
cases were treated, with a total effective rate of 83%, markedly effective rate
21.4%.
Excerpt
from A Guide to TCM Products, China Academy of Traditional Chinese
Medicine, 2003
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.